Trinh Xuan Thuan was born on 20th August, 1948 in Hanoï (Vietnam). He left Hanoi at the age of 6, when Vietnam was divided into two parts at the 17th parallel by the Geneva treaty, signed in 1954. His family then moved to Sàigon, capital of South Vietnam. He pursued his studies in Saigon, at the French high-school Jean-Jacques Rousseau. It is during that period that he acquired the French style that allowed him to write in French such great popular books on astrophysics and cosmology, that are famous not only for their scientific accuracy, but also for their poetic language. He passes with high honors the baccalaureate degree in 1966.

He then went abroad for his higher education. After one year in Switzerland (1966-1967), at the Ecole Polytechnique in Lausanne, he continued his studies in well-known American universities. He obtained his Bachelor of Physics at the California Institute off Technology (Caltech) in 1970, then his PhD in Astrophysics at Princeton University in 1974, under the guidance of the eminent astrophysicist Lyman Spitzer, father of the Hubble space Telescope and one of the pioneers of the physics of the interstellar medium and of plasmas.